Efalizumab

Efalizumab^?
Therapeutic monoclonal antibody
Source	Human
Target	CD11a
Identifiers
CAS number	214745-43-4
ATC code	L04AA21
PubChem	?
DrugBank	BTD00074
Chemical data
Formula	?
Mol. mass	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Efalizumab (Raptiva, Genentech, Merck Serono) is a medication used to treat psoriasis. As its name implies, it is a recombinant humanized monoclonal antibody that binds to CD11a and acts as an immunosuppressant. It is administered once weekly by subcutaneous injection.

It acts to inhibit white blood cell migration out of blood vessels into tissues.

This monoclonal antibody-related article is a stub. You can help Wikipedia by expanding it.

v • d • e

Extracellular

Antibodies	CD3 (Muromonab-CD3, Teplizumab, Visilizumab) · CD4 (Keliximab, Zanolimumab) · CD11a (Efalizumab) · CD20 (Ocrelizumab, Pascolizumab) · CD23 (Lumiliximab) · IL-2/CD25 (Basiliximab, Daclizumab, Inolimomab) · CD40 (Teneliximab) · CD62L/L-selectin (Aselizumab) · CD147/Basigin (Gavilimomab, Ziralimumab) · CD154 (Ruplizumab) BLyS (Belimumab) · Complement component 5 (Eculizumab) · CTLA-4 (Ipilimumab) · CAT (Metelimumab) · Immunoglobulin E (Omalizumab) · Integrin (Natalizumab) · Interleukin 5 (Mepolizumab) · Interleukin-6 receptor (Tocilizumab) · TNFs (Infliximab, Adalimumab, Certolizumab pegol, Afelimomab, Golimumab) · LFA-1 (Odulimomab) other monoclonal: Atlizumab, Atorolimumab, Bertilimumab, Cedelizumab, Clenoliximab, Dorlimomab aritox, Dorlixizumab, Elsilimomab, Erlizumab, Faralimomab, Fontolizumab, Galiximab, Gantenerumab, Gomiliximab, Ibalizumab, Lebrilizumab, Lerdelimumab, Maslimomab, Morolimumab, Nerelimomab, Otelixizumab, Pexelizumab, Reslizumab, Rovelizumab, Siplizumab, Talizumab, Telimomab aritox, Toralizumab, Ustekinumab, Vapaliximab, Vepalimomab, Zolimomab aritox Polyclonal: Anti-thymocyte globulin

-cept (Fusion protein)	Abatacept, Aflibercept, Alefacept, Belatacept, Rilonacept, TNF inhibitor (Etanercept)

IL-1 receptor antagonists	Anakinra

Intracellular

Antimetabolites	purine synthesis inhibitor: Azathioprine, Mycophenolic acid pyrimidine synthesis inhibitor: Leflunomide antifolate: Methotrexate

Macrolides/ other IL-2 inhibitors	diminished production, FKBP/Cyclophilin/Calcineurin: Tacrolimus, Ciclosporin, Pimecrolimus diminished response, mTOR: Sirolimus, Deforolimus, Everolimus, Temsirolimus, Zotarolimus other: Abetimus, Gusperimus

TNF-a inhibitor	Thalidomide

v • d • e Humanized monoclonal antibodies ("-zu-")

"-tuzu-" (tumor)	Alemtuzumab, Bevacizumab/Ranibizumab, Bivatuzumab mertansine, Cantuzumab mertansine, Dacetuzumab, Elotuzumab, Etaracizumab, Etaratuzumab, Gemtuzumab ozogamicin, Inotuzumab ozogamicin, Labetuzumab, Lintuzumab, Matuzumab, Nimotuzumab, Pertuzumab, Sibrotuzumab, Sontuzumab, Tacatuzumab tetraxetan, Trastuzumab, Tucotuzumab celmoleukin

"-lizu-" (immune system)	Aselizumab, Atlizumab, Apolizumab, Cedelizumab, Certolizumab pegol, Daclizumab, Eculizumab, Efalizumab, Epratuzumab, Erlizumab, Fontolizumab, Ibalizumab, Lebrilizumab, Mepolizumab, Natalizumab, Ocrelizumab, Omalizumab, Pascolizumab, Pexelizumab, Reslizumab, Rovelizumab, Ruplizumab, Siplizumab, Talizumab, Teplizumab, Tocilizumab, Toralizumab, Visilizumab

"-bazu-" (bacterial)	Tefibazumab

"-cizu-" (cardiovascular)	Bevacizumab, Tadocizumab

"-neuzu-" (nervous system)	Bapineuzumab

"-toxazu-" (toxin as target)	Urtoxazumab

"-vizu-" (viral infections)	Felvizumab, Motavizumab, Palivizumab, PRO 140

WANT TO ADVERTISE ON ALL OF OVER 11 MILLION SUBPAGES WE HAVE ON THIS SITE FOR UNDER $15? CLICK HERE!