Keliximab

Keliximab^?
Therapeutic monoclonal antibody
Source	Chimeric
Target	CD4
Identifiers
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PubChem	?
Chemical data
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Mol. mass	?
Pharmacokinetic data
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Therapeutic considerations
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Legal status
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Keliximab is a chimeric monoclonal antibody which is used as an immunosuppressive drug.

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v • d • e

Intracellular
(signal initiation)

Antimetabolites	purine synthesis inhibitor: Azathioprine · Mycophenolic acid pyrimidine synthesis inhibitor: Leflunomide · Teriflunomide antifolate: Methotrexate

Macrolides/ other IL-2 inhibitors	FKBP/Cyclophilin/Calcineurin: Tacrolimus · Ciclosporin · Pimecrolimus Abetimus · Gusperimus

TNF-α inhibitor	Thalidomide

Extracellular

Serum target (noncellular)	Complement component 5 (Eculizumab) · TNFs (Infliximab, Adalimumab, Certolizumab pegol, Afelimomab, Golimumab, Nerelimomab) · Interleukin 5 (Mepolizumab) · Immunoglobulin E (Omalizumab) Interferon (Faralimomab) IL-6 (Elsilimomab) IL-12 and IL-13 (Ustekinumab)

Cellular target	CD3 (Muromonab-CD3, Otelixizumab, Teplizumab, Visilizumab) · CD4 (Clenoliximab, Keliximab, Zanolimumab) · CD11a (Efalizumab) · CD18 (Erlizumab) · CD20 (Ocrelizumab, Pascolizumab) · CD23 (Lumiliximab) · CD40 (Teneliximab, Toralizumab) · CD62L/L-selectin (Aselizumab) · CD80 (Galiximab) · CD147/Basigin (Gavilimomab, Ziralimumab) · CD154 (Ruplizumab) BLyS (Belimumab) · CTLA-4 (Ipilimumab, Tremelimumab) · CAT (Bertilimumab, Lerdelimumab, Metelimumab) · Integrin (Natalizumab) · Interleukin-6 receptor (Tocilizumab) · LFA-1 (Odulimomab) IL-2 receptor/CD25 (Basiliximab, Daclizumab, Inolimomab) T-lymphocyte (Zolimomab aritox)

Unsorted	Atlizumab, Atorolimumab, Cedelizumab, Dorlimomab aritox, Dorlixizumab, Fontolizumab, Gantenerumab, Gomiliximab, Lebrilizumab, Maslimomab, Morolimumab, Pexelizumab, Reslizumab, Rovelizumab, Siplizumab, Talizumab, Telimomab aritox, Vapaliximab, Vepalimomab

Intracellular
(signal reception)

IL-1 receptor antagonists	Anakinra

mTOR	Sirolimus · Deforolimus · Everolimus · Temsirolimus · Zotarolimus

v • d • e Chimeric monoclonal antibodies ("-xi-")

"-tuxi-" (tumor/cancer immunotherapy)	Bavituximab, Cetuximab, Rituximab

"-cixi-" (cardiovascular)	Abciximab, Volociximab

"-lixi-" (immune system)	Basiliximab, Clenoliximab, Galiximab, Gomiliximab, Infliximab, Keliximab, Lumiliximab, Teneliximab, Vapaliximab

"-mexi-" (melanoma)	Ecromeximab

"-baxi-" (bacterial)	Pagibaximab

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